Flutamide is a non-steroidal antiandrogen that is devoid of other hormonal activity. It most likely acts after converting to 2-hydroxyflutamide, which is a potent competitive inhibitor of dihydrotestosterone (DHT) binding to the androgen receptor. Flutamide is currently approved for the treatment of prostate cancer in combination with luteinizing hormone-releasing hormone
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Progesterone is a compound that has high structural similarity to testosterone, and therefore can use the same enzymes (5 alpha – Reductase), and bind to the androgen receptor. Some progestins (synthetic progesterone) have inherent estrogenic as well as androgenic effects. Although progesterone binds to its own intracellular transcription receptor, it
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All steroid hormones act by diffusing through the plasma membrane into the target cell and binding to specific intracellular receptors. Similarly, androgens, like other steroids, diffuse across plasma membranes and combine with a cytosolic or nuclear receptor protein. The cytosol is the internal fluid of the cell where a large
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Androgens are a family of hormones that promote the development and maintenance of male sex characteristics. Androgens are also the mediators of terminal hair growth throughout the body, i.e., with sexual maturity they cause enlargement of vellus hairs to form terminal hair in the axilla and pubis in both sexes,
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Androgenetic alopecia, also known as common baldness, hereditary baldness and androgenic alopecia, is the most common form of hair loss. It is recognizable due to the distinctive pattern of progression of the hair loss on the scalp. Although androgenetic alopecia is an extremely common disorder affecting men and women, the
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