Hamilton observed that when men with male pattern baldness were castrated it prevented further progression of hair loss; and that the hair loss in eunuchs induced by exogenous testosterone halted when testosterone treatment was discontinued. This leads to the assumption that it would be feasible to use an antiandrogen to
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All steroid hormones act by diffusing through the plasma membrane into the target cell and binding to specific intracellular receptors. Similarly, androgens, like other steroids, diffuse across plasma membranes and combine with a cytosolic or nuclear receptor protein. The cytosol is the internal fluid of the cell where a large
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Research studies in patients with androgen insensitivity syndromes and 5alpha – reductase type-2 deficiencies indicate that androgenetic alopecia is induced by activation of follicular androgen receptors by dihydrotestosterone (DHT), a potent stimulator of hair loss in the scalp. Although the level of DHT may be directly dependent on the activity
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Androgens are a family of hormones that promote the development and maintenance of male sex characteristics. Androgens are also the mediators of terminal hair growth throughout the body, i.e., with sexual maturity they cause enlargement of vellus hairs to form terminal hair in the axilla and pubis in both sexes,
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Scientists and hair biologists today are of the opinion that the loss of scalp hair in genetically susceptible individuals is mediated by androgens. Aristotle first noted that ‘maleness’ and sexual maturity were required for balding. Later in 1942, Hamilton’s observations on men deprived of testicular androgens by castration ascertained that
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